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An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma

2025-09-21

Abstract excerpt

Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Over 75% of HCC cases are associated with chronic viral infections. Mechanistic studies and preclinical therapeutic development for virus-associated HCC have been limited by a paucity of small animal models of chronic hepatotropic virus infection that faithfully recapitulate human disease. Here we demonstrate the induction of chronic hepatitis...

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Literature Corpus work
9fa1c658-e4c1-5e29-b2e1-519f0f5b6e80
DOI
10.1101/2025.09.19.677076
Open publication

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An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinomaDOI 10.1101/2025.09.19.677076
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