Article

Rheumatoid Arthritis-associated IgG N-glycan agalactosylation diminishes neutrophilic inflammation by reducing FcγR binding and downstream signaling

2026-07-07

Abstract excerpt

<h4>Summary</h4> The IgG Fc chain carries a single N-linked glycan which may undergo changes. Increased agalactosylated N-glycans are associated with rheumatoid arthritis (RA) and regarded as pro-inflammatory. Dysregulated neutrophils can make important contributions to host tissue damage. In RA, immune complexes (ICs) that have precipitated onto synovial joint surfaces activate neutrophils via Fc receptors, prom...

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Literature Corpus work: 0df602a8-ecfd-5335-80ef-f7d0e28d9dea
DOI: 10.64898/2026.07.02.735866

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