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Cancer models, genomic instability and somatic cellular Darwinian evolution

1 Jan 2010

Abstract excerpt

The biology of cancer is critically reviewed and evidence adduced that its development can be modelled as a somatic cellular Darwinian evolutionary process. The evidence for involvement of genomic instability (GI) is also reviewed. A variety of quasi-mechanistic models of carcinogenesis are reviewed, all based on this somatic Darwinian evolutionary hypothesis; in particular, the multi-stage model of Armitage and...

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PMID: 20406436
DOI: 10.1186/1745-6150-5-19

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