Article

Mass spectral feature analysis of ubiquitylated peptides provides insights into probing the dark ubiquitylome

2024-05-17

Abstract excerpt

Ubiquitylation is a structurally and functionally diverse post translational modification that involves the covalent attachment of the small protein ubiquitin to other protein substrates. Trypsin-based proteomics is the most common approach for globally identifying ubiquitylation sites. However, we estimate that such methods are unable to detect ~40% of ubiquitylation sites in the human proteome - i.e., the dark u...

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Literature Corpus work: 7a847569-07d3-5987-b04b-104843938ffc
DOI: 10.1101/2024.05.16.594577

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