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Non-proteolytic ubiquitylation in cellular signaling and human disease

8 Feb 2022

Abstract excerpt

Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However it can also result in non-proteolytic events which play important functions in cellular processes such as intracellular signaling, membrane trafficking, DNA repair and cell cycle. Emerging evidence demonstrates that dysfunction of non-proteolytic...

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PMID: 35136173
DOI: 10.1038/s42003-022-03060-1

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