Back to search

Article

Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion

2025-12-03

Abstract excerpt

Ubiquitination is central to skin homeostasis and disease, however the cutaneous ubiquitinome remains poorly characterised. We investigated spatial patterns of ubiquitination in human skin, discovering specific ubiquitin linkages located within the hair follicle and epidermis. To create a comprehensive physiological profile of the ubiquitinated proteins within the skin, we profiled healthy skin and CYLD cutaneous...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5cda0a94-ae2c-5796-8767-492d3a0d61c1
DOI
10.64898/2025.12.03.691868
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretionDOI 10.64898/2025.12.03.691868
Deubiquitylases From Genes to OrganismSemantic proximity
Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer TypesSemantic proximity
Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes.Semantic proximity
The ubiquitin system, disease, and drug discovery.Semantic proximity
Emerging Roles of Non-proteolytic Ubiquitination in TumorigenesisSemantic proximity
Survey of the human proteostasis network: the ubiquitin-proteasome systemSemantic proximity
Integrative and Comprehensive Pan-cancer Analysis of Ubiquitin Specific Peptidase 11 (USP11) As a Prognostic and Immunological BiomarkerSemantic proximity
Diseased skin dermal proteomic profiles reflect shared extracellular matrix dysregulation patternsSemantic proximity
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implicationsSemantic proximity
Mass spectral feature analysis of ubiquitylated peptides provides insights into probing the dark ubiquitylomeSemantic proximity
Linear ubiquitination at a glanceSemantic proximity
Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility.Semantic proximity
Select a neighboring publication to make it the new centre.