Article

NR4A3 deficiency ameliorates contact hypersensitivity and exacerbates psoriasis by regulating gene expression in dendritic cells

2024-02-21

Abstract excerpt

NR4A3 is a transcription factor that belongs to the nuclear receptor superfamily. To reveal the roles of NR4A3 in skin diseases, we constructed contact hypersensitivity (CHS)- and imiquimod-induced psoriasis models in Nr4a3 -/- mice. In the CHS induced Nr4a3 -/- mice, ear swelling was significantly reduced, accompanied by suppressed migration of dendritic cells (DCs), in which CCR7 expression was reduced. In con...

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Literature Corpus work: 05710d27-5525-57da-980e-b97d6be46f33
DOI: 10.1101/2024.02.20.581116

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