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Article

Multi-target RNA interference: A disruptive next-generation strategy for precision treatment of rheumatoid arthritis

19 May 2025

Abstract excerpt

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic joint inflammation. Existing therapeutic regimens, including disease-modifying anti-rheumatic drugs (DMARDs) and biologics, exhibit incomplete efficacy and pronounced limitations. RNA interference (RNAi) utilizing small interfering RNA (siRNA) facilitates the precise silencing of key pathological drivers in rheumatoid arthritis (RA), such...

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PMID: 40394795
DOI: 10.1016/j.intimp.2025.114890

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