Article

TEAD4 integrates IFN-γ and TGF-β signaling to drive pathogenic synovial fibroblast programs in difficult-to-treat rheumatoid arthritis

2026-06-11

Abstract excerpt

<title>Abstract</title> Difficult-to-treat rheumatoid arthritis (D2T RA) remains a major unmet clinical challenge, with synovial fibroblasts increasingly recognized as key drivers of persistent inflammation and treatment resistance. Recent single cell and spatial transcriptomic studies have identified pathogenic fibroblast subsets, including sublining DKK3⁺, THY1 high , ITGA5⁺, and COMP hi...

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Literature Corpus work: 9943170c-ac45-5127-a0bf-ff85251624b8
DOI: 10.21203/rs.3.rs-9652440/v1

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