Article

Ovarian Hormones Moderate Systolic Hypertension in Female <i>Eln</i> Haploinsufficient Mice

2025-11-18

Abstract excerpt

Hypertension is a hallmark of cardiovascular abnormalities associated with Williams syndrome (WS), a rare genetic disorder involving microdeletion of genes on human chromosome 7, including the elastin gene ( ELN ). Heterozygous deletion of Eln ( Eln +/− ) in mice recapitulates hypertension and arteriopathy associated with WS. Previously, differences in blood pressure elevation and sensitivity to dietary sodium...

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Literature Corpus work: 7a75e1a9-56c4-5ca0-bd83-797c75f15e05
DOI: 10.1101/2025.11.18.689164

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