Article
Estrogen actions in the male reproductive system involve estrogen response element-independent pathways.
Endocrinology - 1 Dec 2008
Weiss Jeffrey, Bernhardt Miranda L, Laronda Monica M, Hurley Lisa A, Glidewell-Kenney Christine, Pillai Suresh, Tong Minghan, Korach Kenneth S, Jameson J Larry
Abstract excerpt
The estrogen receptor-alpha (ERalpha) acts through multiple pathways, including estrogen response element (ERE)-dependent (classical) and ERE-independent (nonclassical) mechanisms. We previously created a mouse model harboring a two-amino-acid mutation of the DNA-binding domain (E207A, G208A) that precludes direct binding of ERalpha to an ERE. After crossing heterozygous mutant mice with an ERalpha knockout...
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