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Article

Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2012

Craigie Eilidh, Evans Louise C, Mullins John J, Bailey Matthew A

Abstract excerpt

In vivo, the enzyme 11β-hydroxysteroid dehydrogenase type 2 influences ligand access to the mineralocorticoid receptor. Ablation of the encoding gene, HSD11B2, causes the hypertensive syndrome of apparent mineralocorticoid excess. Studies in humans and experimental animals have linked reduced 11β-hydroxysteroid dehydrogenase type 2 activity and salt sensitivity of blood pressure. In the present study, renal...

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Source

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Identifiers

PMID: 22777941
DOI: 10.1161/HYPERTENSIONAHA.112.196410
PMCID: PMC3428628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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