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Article

Estrogen-regulated renal progenitors determine pregnancy adaptation and preeclampsia

4 Sept 2025

Abstract excerpt

The global burden of kidney disease displays marked sexual dimorphism. Lineage tracing and single-cell RNA-sequencing revealed that starting from puberty, estrogen signaling in female mice supports self-renewal and differentiation of renal progenitors to increase filtration capacity, reducing sensitivity to glomerular injury compared with that of males. This phenomenon accelerated as female kidneys adapted to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40906846
DOI: 10.1126/science.adp4629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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