ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice

Abstract excerpt

Modeling a pregnancy disorder Preeclampsia, a dangerous pregnancy disorder marked by high blood pressure, can lead to premature birth and be life-threatening to the mother and baby. Research leading to effective treatments has been hampered by a lack of informative animal models. Ho et al. identified ELABELA as a hormone produced by the placenta whose levels are lower in preeclampsia (see the Perspective by Wirka...

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