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Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome

1 Jan 2000

Abstract excerpt

Generation of RNA dimeric form of the human immunodeficiency virus type 1 (HIV-1) genome is crucial for viral replication. The dimerization initiation site (DIS) has been identified as a primary sequence that can form a stem-loop structure with a self-complementary sequence in the loop and a bulge in the stem. It has been reported that HIV-1 RNA fragments containing the DIS form two types of dimers, loose dimers...

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PMID: 10668802
DOI: 10.1017/s1355838200991635

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