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Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell

28 Apr 2006

Abstract excerpt

The kissing-loop complex that initiates dimerization of genomic RNA is crucial for Human Immunodeficiency Virus Type 1 (HIV-1) replication. We showed that owing to its strong similitude with the bacterial ribosomal A site it can be targeted by aminoglycosides. Here, we present its crystal structure in complex with neamine, ribostamycin, neomycin and lividomycin. These structures explain the specificity for...

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PMID: 16679451
DOI: 10.1093/nar/gkl317

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