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Article

Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics.

Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2025

Romeo Stefano, Valenti Luca

Abstract excerpt

Steatotic liver disease (SLD), caused by excess lipid accumulation in hepatocytes, is now a leading global liver condition triggered by metabolic dysfunction, alcohol, toxins and heritable factors. The main genetic determinant is the common PNPLA3 p.I148M variant, which explains a substantial portion of SLD interindividual and interethnic variability, up to a quarter of liability to cirrhosis and liver cancer in...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lipase

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Share to Phospholipases A2, Calcium-Independent

Source

Open in PubMed Open full text

Identifiers

PMID: 40747912
DOI: 10.1111/liv.70240
PMCID: PMC12315499

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics.PMID 40747912Read ↗

PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date.Semantic proximity Read ↗

Contribution of PNPLA3 gene to the natural history of liver diseases.Semantic proximity Read ↗

PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease.Semantic proximity Read ↗

PNPLA3 in Alcohol-Related Liver Disease.Semantic proximity Read ↗

Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease.Semantic proximity Read ↗

Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD.Semantic proximity Read ↗

Genetics in Common Liver Diseases: From Pathophysiology to Precise Treatment.Semantic proximity Read ↗

Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis.Semantic proximity Read ↗

Targeting PNPLA3 to Treat MASH and MASH Related Fibrosis and Cirrhosis.Semantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

PNPLA3—A Potential Therapeutic Target for Personalized Treatment of Chronic Liver DiseaseSemantic proximity Read ↗

Function of PNPLA3 I148M-Lessons From In Vivo Studies in Humans.Semantic proximity Read ↗

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