Article
Modeling PNPLA3-Associated NAFLD Using Human-Induced Pluripotent Stem Cells.
Hepatology (Baltimore, Md.) - 1 Dec 2021
Tilson Samantha G, Morell Carola M, Lenaerts An-Sofie, Park Seung Bum, Hu Zongyi, Jenkins Benjamin, Koulman Albert, Liang T Jake, Vallier Ludovic
Abstract excerpt
BACKGROUND AND AIMS: NAFLD is a growing public health burden. However, the pathogenesis of NAFLD has not yet been fully elucidated, and the importance of genetic factors has only recently been appreciated. Genomic studies have revealed a strong association between NAFLD progression and the I148M variant in patatin-like phospholipase domain-containing protein 3 (PNPLA3). Nonetheless, very little is known about the...
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