Article
Streptomyces coelicolor strains lacking polyprenol phosphate mannose synthase and protein O-mannosyl transferase are hyper-susceptible to multiple antibiotics.
Microbiology (Reading, England) - 1 Mar 2018
Howlett Robert, Read Nicholas, Varghese Anpu, Kershaw Charles, Hancock Y, Smith Margaret C M
Abstract excerpt
Polyprenol phosphate mannose (PPM) is a lipid-linked sugar donor used by extra-cytoplasmic glycosyl tranferases in bacteria. PPM is synthesized by polyprenol phosphate mannose synthase, Ppm1, and in most Actinobacteria is used as the sugar donor for protein O-mannosyl transferase, Pmt, in protein glycosylation. Ppm1 and Pmt have homologues in yeasts and humans, where they are required for protein O-mannosylation....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.