Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect.

doi:10.1186/s12864-018-4838-z

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Article

Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect.

BMC genomics - 14 Jun 2018

Santos-Beneit Fernando

Abstract excerpt

BACKGROUND: Glycopeptide antibiotics inhibit bacterial cell-wall synthesis, and are important for the treatment of infections caused by multi drug-resistant strains of enterococci, streptococci and staphylococci. The main mechanism by which bacteria resist the action of glycopeptides is by producing a modified cell-wall in which the dipeptide D-Alanine-D-Alanine is substituted by D-Alanine-D-Lactate or...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Genes, Reporter
Genome, Plant
Microfluidic Analytical Techniques
Muramidase
Mutation
Phosphates
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Streptomyces coelicolor
Vancomycin
Vancomycin Resistance

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Identifiers

PMID: 29898657
DOI: 10.1186/s12864-018-4838-z
PMCID: PMC6001138

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