Article

Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size

2022-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Despite substantial progress in identifying and understanding causative mutations in autosomal dominant polycystic kidney disease (ADPKD), little is known about subsequent cellular events leading to cyst formation. In prior studies we reported that Cadherin 8, a type II Cadherin, expression is sufficient to induce cyst emergence from HK-2 cells grown as tubule arrays in collagen matrix (1). Howe...

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Literature Corpus work: 7a480fe9-baa8-5237-bf13-ff8d3e3a7cd1
DOI: 10.1101/2022.03.01.482118

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