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Article

Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.

Journal of the American Society of Nephrology : JASN - 1 Nov 2015

Lehmann Holger, Vicari Daniele, Wild Peter J, Frew Ian J

Abstract excerpt

A subset of familial and sporadic clear cell renal cell carcinomas (ccRCCs) is believed to develop from cystic precursor lesions. Loss of function of the von Hippel-Lindau tumor suppressor gene (VHL) predisposes renal epithelial cells to loss of the primary cilium in response to specific signals. Because the primary cilium suppresses renal cyst formation, loss of the cilium may be an initiating event in the...

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Identifiers

PMID: 25788526
DOI: 10.1681/ASN.2014090875
PMCID: PMC4625677

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.PMID 25788526Read ↗

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Combined mutation of Vhl and Trp53 causes renal cysts and tumours in miceSemantic proximity Read ↗

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