Article
Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic disease.
Molecular biology of the cell - 7 Nov 2016
Belmonte Julio M, Clendenon Sherry G, Oliveira Guilherme M, Swat Maciej H, Greene Evan V, Jeyaraman Srividhya, Glazier James A, Bacallao Robert L
Abstract excerpt
In autosomal dominant polycystic kidney disease (ADPKD), cysts accumulate and progressively impair renal function. Mutations in PKD1 and PKD2 genes are causally linked to ADPKD, but how these mutations drive cell behaviors that underlie ADPKD pathogenesis is unknown. Human ADPKD cysts frequently express cadherin-8 (cad8), and expression of cad8 ectopically in vitro suffices to initiate cystogenesis. To explore...
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