Article

High performance intensiometric direct- and inverse-response genetically encoded biosensors for citrate

2020-04-13

Abstract excerpt

Motivated by the growing recognition of citrate as a central metabolite in a variety of biological processes associated with healthy and diseased cellular states, we have developed a series of high-performance genetically encoded citrate biosensors suitable for imaging of citrate concentrations in mammalian cells. The design of these biosensors was guided by structural studies of the citrate-responsive sensor hist...

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Literature Corpus work: 7a42d672-88f1-5458-8784-0aa6268cec41
DOI: 10.1101/2020.04.12.038547

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