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R103 and R115 Affinity Mutants of ATeam ATP Biosensors.

Sensors (Basel, Switzerland) - 6 Oct 2025

Cholger Autumn, Conley Jason M, Valentino Stephen A, Colomb Elaine, de Cuba Olivia, Kress Jacob, Tantama Mathew

Abstract excerpt

Adenosine triphosphate (ATP) varies from nanomolar to millimolar levels across the physiological landscapes in which it serves as an energy carrier, phosphate donor, and purinergic signaling molecule. To measure these vastly different concentrations, genetically encoded sensors with different affinities are needed to match the particular ATP range and application. To this end, we mutagenized two key arginine...

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PMID: 41095002
DOI: 10.3390/s25196180
PMCID: PMC12527034

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