Article

Flexibly encoded genome-wide association study identifies novel nonadditive genetic risk variants for cardiometabolic traits

2023-06-05

Abstract excerpt

Most genome-wide association studies (GWAS) assume an additive inheritance model, which assigns heterozygous genotypes half the risk of homozygous-alternate genotypes. This has led to a focus on additive genetic effects in complex disease research. Growing evidence indicates that many single-nucleotide polymorphisms (SNPs) have nonadditive effects, including dominant and recessive effects, which are missed by the...

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Literature Corpus work: 7a18f7d8-9662-54b7-8a48-a1168eeb84f2
DOI: 10.1101/2023.06.01.23290857

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