Article
Novel EDGE encoding method enhances ability to identify genetic interactions.
PLoS genetics - 1 Jun 2021
Hall Molly A, Wallace John, Lucas Anastasia M, Bradford Yuki, Verma Shefali S, Müller-Myhsok Bertram, Passero Kristin, Zhou Jiayan, McGuigan John, Jiang Beibei, Pendergrass Sarah A, Zhang Yanfei, Peissig Peggy, Brilliant Murray, Sleiman Patrick, Hakonarson Hakon, Harley John B, Kiryluk Krzysztof, Van Steen Kristel, Moore Jason H, Ritchie Marylyn D
Abstract excerpt
Assumptions are made about the genetic model of single nucleotide polymorphisms (SNPs) when choosing a traditional genetic encoding: additive, dominant, and recessive. Furthermore, SNPs across the genome are unlikely to demonstrate identical genetic models. However, running SNP-SNP interaction analyses with every combination of encodings raises the multiple testing burden. Here, we present a novel and flexible...
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