Article
Trim24 targets endogenous p53 for degradation.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jul 2009
Allton Kendra, Jain Abhinav K, Herz Hans-Martin, Tsai Wen-Wei, Jung Sung Yun, Qin Jun, Bergmann Andreas, Johnson Randy L, Barton Michelle Craig
Abstract excerpt
Numerous studies focus on the tumor suppressor p53 as a protector of genomic stability, mediator of cell cycle arrest and apoptosis, and target of mutation in 50% of all human cancers. The vast majority of information on p53, its protein-interaction partners and regulation, comes from studies of tumor-derived, cultured cells where p53 and its regulatory controls may be mutated or dysfunctional. To address...
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