Article

TXNDC15 modulated quality control at the endoplasmic reticulum shapes ciliogenesis

2026-04-02

Abstract excerpt

<h4>SUMMARY</h4> At the endoplasmic reticulum (ER), membrane protein quality control is tightly regulated to ensure excess subunits are recognized and degraded to protect cellular homeostasis. Using genome wide CRISPR screens, we identified a factor of unknown function, thioredoxin domain containing protein 15 (TXNDC15), and showed that it regulates membrane protein stability by tuning the activity of the E3-ubiq...

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Literature Corpus work: 31111229-115a-5d09-804c-85cbfb17b158
DOI: 10.64898/2026.04.01.715963

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