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Article

TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.

Experimental cell research - 1 Aug 2005

Kallijärvi Jukka, Lahtinen Ulla, Hämäläinen Riikka, Lipsanen-Nyman Marita, Palvimo Jorma J, Lehesjoki Anna-Elina

Abstract excerpt

Mulibrey nanism is an autosomal recessive prenatal-onset growth disorder characterized by dysmorphic features, cardiomyopathy, and hepatomegaly. Mutations in TRIM37 encoding a tripartite motif (TRIM, RING-B-box-coiled-coil)-family protein underlie mulibrey nanism. We investigated the ubiquitin ligase activity predicted for the RING domain of TRIM37 by analyzing its autoubiquitination. Full-length TRIM37 and its...

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Source

Identifiers

PMID: 15885686
DOI: 10.1016/j.yexcr.2005.04.001

Genes

TRIM37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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