Article

Accurate, sensitive, and efficient chromatin accessibility quantification at target loci using UNIChro-seq

2025-07-29

Abstract excerpt

Recent progress in statistical and experimental fine mapping of disease risk variants prompts us to focus on specific target loci for functional investigation. However, current genetics is hindered by a limited toolbox for target-loci analysis. To address this, we developed UNIChro-seq, a method that digitally counts accessible chromatin molecules at target loci. UNIChro-seq allows for accurate, sensitive, and eff...

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Literature Corpus work: 79f5c176-46ec-5669-8cf9-800d52059d41
DOI: 10.1101/2025.07.29.25332340

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