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Article

Accurate, sensitive, and efficient chromatin accessibility quantification at target loci using UNIChro-seq.

Nature communications - 20 Jul 2026

Kono Michihiro, Hatano Hiroaki, Asahara Kenichiro, Nakano Masahiro, Bagherzadeh Reza, Kawashima Tsugumi, Arakawa Takahiro, Sato Miho, Inokuchi Hajime, Nishino Takahiro, Itamiya Takahiro, Takahashi Haruka, Natsumoto Bunki, Suzuki Akari, Yamamoto Kazuhiko, Ishigaki Kazuyoshi

Abstract excerpt

Recent progress in statistical and experimental fine mapping of disease risk variants prompts us to focus on specific target loci for functional investigation. However, current genetics is hindered by a limited toolbox for target-loci analysis. To address this, we present UNIChro-seq, a method that digitally counts accessible chromatin molecules at target loci. UNIChro-seq allows for accurate, sensitive, and...

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Identifiers

PMID: 42477366
DOI: 10.1038/s41467-026-75767-2
PMCID: PMC13493992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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