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Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons

2024-09-20

Abstract excerpt

<h4>SUMMARY</h4> Persistent DNA double-strand breaks (DSBs) are enigmatically implicated in neurodegenerative diseases including Huntington’s disease (HD), the inherited late-onset disorder caused by CAG repeat elongations in Huntingtin (HTT). Here we combine biochemistry, computation and molecular cell biology to unveil a mechanism whereby HTT coordinates a Transcription-Coupled Non-Homologous End-Joining (TC-NH...

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Literature Corpus work
79e68f28-7e8a-538b-b1fe-6d6715a867a3
DOI
10.1101/2024.09.19.613927
Open publication

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Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neuronsDOI 10.1101/2024.09.19.613927
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