Article

Double strand breaks drive toxicity in Huntington’s disease mice with or without somatic expansion

2025-05-28

Abstract excerpt

<h4>ABSTRACT</h4> There has been a substantial investment in elucidating the mechanism of expansion in hopes of identifying therapeutic targets for Huntington disease (HD). Although an expanded CAG allele is the causal mutation for HD, there is evidence that somatic expansion may not be the only disease driver. We report here that double strand breaks (DSBs) drive HD toxicity by an independent mechanism from soma...

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Literature Corpus work: 49b5d2e4-371a-55e3-9941-2b45538a0a9c
DOI: 10.1101/2025.05.27.654663

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