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Article

Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.

Human molecular genetics - 1 Mar 2014

Barclay Sam S, Tamura Takuya, Ito Hikaru, Fujita Kyota, Tagawa Kazuhiko, Shimamura Teppei, Katsuta Asuka, Shiwaku Hiroki, Sone Masaki, Imoto Seiya, Miyano Satoru, Okazawa Hitoshi

Abstract excerpt

DNA damage repair is implicated in neurodegenerative diseases; however, the relative contributions of various DNA repair systems to the pathology of these diseases have not been investigated systematically. In this study, we performed a systematic in vivo screen of all available Drosophila melanogaster homolog DNA repair genes, and we tested the effect of their overexpression on lifespan and developmental...

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Identifiers

PMID: 24179173
DOI: 10.1093/hmg/ddt524

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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