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Article

DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.

Gut - 1 Oct 2020

Krishnan Vaidehi, Lim Debbie Xiu En, Hoang Phuong Mai, Srivastava Supriya, Matsuo Junichi, Huang Kie Kyon, Zhu Feng, Ho Khek Yu, So Jimmy Bok Yan, Khor Christopher, Tsao Stephen, Teh Ming, Fock Kwong Ming, Ang Tiing Leong, Jeyasekharan Anand D, Tan Patrick, Yeoh Khay-Guan, Ito Yoshiaki

Abstract excerpt

OBJECTIVE: Intestinal metaplasia (IM) is a premalignant stage that poses a greater risk for subsequent gastric cancer (GC). However, factors regulating IM to GC progression remain unclear. Previously, activated DNA damage response (DDR) signalling factors were shown to engage tumour-suppressive networks in premalignant lesions. Here, we interrogate the relationship of DDR signalling to mutational accumulation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31937549
DOI: 10.1136/gutjnl-2019-319002
PMCID: PMC7497583

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