Article

Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas

2022-07-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and aims</h4> DNA repair deficiency is a common feature of cancer. Homologous recombination (HR) and nucleotide excision repair (NER) are the two most frequently disabled DNA repair pathways in solid tumors. HR deficient breast, ovarian, pancreatic and prostate cancers respond well to platinum chemotherapy and PARP inhibitors. However, the frequency of DNA repair pathway deficien...

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Literature Corpus work: db077dfc-7d9c-5668-b56b-773b2918c388
DOI: 10.1101/2022.07.14.500118

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