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Spatial Computational Hepatic Molecular Biomarker Reveals LSECs Role in Mid Lobular Liver Zonation Fibrosis in DILI and NASH Liver Injury

2024-02-12

Abstract excerpt

Liver is structurally organized into zonation where LSECs endothelial cells play a crucial role during chronic liver injury and early stages of fibrosis. Fibrosis can be reversed if diagnosed early at molecular level in zonation before progressing to advanced stages like bridging fibrosis. This study identified zonation marker genes using scRNA-seq and spatial transcriptomics molecular profiling technologies in no...

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Literature Corpus work: 79d767c5-825f-5d91-8f51-b8cdfe43d5f8
DOI: 10.20944/preprints202402.0665.v1

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