Article

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

2023-10-11

Abstract excerpt

TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic acid-binding protein TDP-43 and subsequent neuronal dysfunction. Here, we developed endogenous models of sporadic TDP-43 proteinopathy based on the principle that disease-associated TDP-43 acetylation at lys...

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Literature Corpus work: 5e4a6911-6079-503a-92b5-0b1587254108
DOI: 10.7554/elife.85921.3

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