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Article

Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.

Human molecular genetics - 1 Nov 2017

Tibshirani Michael, Zhao Beibei, Gentil Benoit J, Minotti Sandra, Marques Christine, Keith Julia, Rogaeva Ekaterina, Zinman Lorne, Rouaux Caroline, Robertson Janice, Durham Heather D

Abstract excerpt

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease with paralysis resulting from dysfunction and loss of motor neurons. A common neuropathological finding is attrition of motor neuron dendrites, which make central connections vital to motor control. The chromatin remodelling complex, neuronal Brahma-related gene 1 (Brg1)-associated factor complex (nBAF), is critical for neuronal differentiation,...

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PMID: 28973294
DOI: 10.1093/hmg/ddx301

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FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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