Article

Nuclear depletion of RNA binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis

2021-06-03

Abstract excerpt

Amyotrophic lateral sclerosis is a progressive fatal neurodegenerative disease caused by loss of motor neurons and characterized neuropathologically in almost all cases by nuclear depletion and cytoplasmic aggregation of TDP-43, a nuclear RNA binding protein (RBP). We identified ELAVL3 as one of the most downregulated genes in our transcriptome profiles of laser captured microdissection of motor neurons from spora...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07ef9df9-5e33-5ae6-9e96-fcbb1bb643d8
DOI: 10.1101/2021.06.03.446017

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nuclear depletion of RNA binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosisDOI 10.1101/2021.06.03.446017Read

Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosisSemantic proximity Read

Single-cell transcriptomics uncovers chromatin dysfunction in a human TDP-43 proteinopathy model of Amyotrophic Lateral SclerosisSemantic proximity Read

Loss of nuclear TDP ‐43 in amyotrophic lateral sclerosis ( ALS ) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neuronesSemantic proximity Read

RNA Dysregulation in Amyotrophic Lateral SclerosisSemantic proximity Read

Amyotrophic Lateral Sclerosis and Other Motor Neuron DiseasesSemantic proximity Read

Emerging mechanisms of molecular pathology in ALSSemantic proximity Read

Amyotrophic lateral sclerosis: an update on recent genetic insights.Semantic proximity Read

3’UTR variants of ALS-linked RNAs modify subcellular and cellular phenotypesSemantic proximity Read

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.Semantic proximity Read

Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?Semantic proximity Read

Novel and known transcriptional targets of ALS/FTD protein TDP-43: Meta-analysis and interactive graphical databasesSemantic proximity Read

TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stabilitySemantic proximity Read