Article

Novel and known transcriptional targets of ALS/FTD protein TDP-43: Meta-analysis and interactive graphical databases

2021-12-09

Abstract excerpt

TDP-43 proteinopathy is the major pathological hallmark of amyotrophic lateral sclerosis (ALS) and tau-negative frontotemporal dementia (FTD). Mounting evidence implicates a loss of normal TDP-43 function in neurodegeneration, either resultant from or independent of TDP-43 aggregation. TDP-43 knockdown is therefore a common paradigm for modelling ALS and FTD. However, because TDP-43 can interact directly with thou...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d312182-22d4-5452-a1d9-1fee5582e3b0
DOI: 10.1101/2021.12.08.471595

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel and known transcriptional targets of ALS/FTD protein TDP-43: Meta-analysis and interactive graphical databasesDOI 10.1101/2021.12.08.471595Read

Proteomics Analysis of the TDP ‐43 Interactome in Cellular Models of ALS PathogenesisSemantic proximity Read

Integrative multiomic analysis links TDP-43-driven splicing defects to cascading proteomic disruption of ALS/FTD pathwaysSemantic proximity Read

Familial ALS/FTD-associated RNA-binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation in vitroSemantic proximity Read

Familial ALS/FTD-associated RNA-Binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation <i>in vitro</i>Semantic proximity Read

Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila.Semantic proximity Read

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924Semantic proximity Read

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteinsSemantic proximity Read

Cell environment shapes TDP-43 function with implications in neuronal and muscle diseaseSemantic proximity Read

TDP-43 loss of function drives aberrant splicing in Parkinson’s diseaseSemantic proximity Read

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924Semantic proximity Read

Decoding TDP-43: the molecular chameleon of neurodegenerative diseasesSemantic proximity Read

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Semantic proximity Read