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M4 drug discovery: human drug predictions from integrated preclinical insights exemplified with a GLP-1R agonist

2025-11-05

Abstract excerpt

<h4>ABSTRACT</h4> A major recent breakthrough in the treatment of type 2 diabetes has been the development of glucagon-like peptide-1 receptor agonists (GLP-1RAs). However, current translational frameworks struggle to predict the clinical outcomes of these drugs from preclinical data. There are several reasons for this struggle, which are generic for many drugs: GLP-1RAs act through multi-timescale mechanisms in...

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Literature Corpus work
799d4008-f154-5800-a2a2-3055176b7610
DOI
10.1101/2025.11.03.686224
Open publication

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M4 drug discovery: human drug predictions from integrated preclinical insights exemplified with a GLP-1R agonistDOI 10.1101/2025.11.03.686224
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