Article

Control of human pancreatic beta cell kinome by GLP-1R biased agonism

2023-02-26

Abstract excerpt

<h4>Aim</h4> To determine the kinase activity profiles of human pancreatic beta cells downstream of GLP-1R balanced versus biased agonist stimulations. <h4>Materials and methods</h4> This study analysed the kinomic profiles of human EndoC-βh1 cells following vehicle and glucagon-like peptide-1 receptor (GLP-1R) stimulation with the pharmacological agonist exendin-4, as well as exendin-4-based biased derivative...

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Literature Corpus work: dc0b045f-e406-58db-b858-16a9c5f036ee
DOI: 10.1101/2023.02.25.530040

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