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A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical Combinations

2026-08-28

Abstract excerpt

<title>Abstract</title> <p>Background: Major depressive disorder (MDD) shows <50% remission even under optimized treatment, with response heterogeneity driven by polygenic, inflammatory, neurocircuit and exposome factors. Mechanistic prediction remains fragmented and often relies on arbitrary statistical weights violating biophysical constraints. <h4>Methods:</h4> We built a mechanistic, multilevel platform with...

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Literature Corpus work
dbcfabe2-c99c-5153-b89c-97886211fe3d
DOI
10.21203/rs.3.rs-10811698/v1
Open publication

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A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical CombinationsDOI 10.21203/rs.3.rs-10811698/v1
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