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Article

Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening

1 May 2022

Abstract excerpt

The E1 and E2 envelope proteins of hepatitis C virus (HCV) form a heterodimer that drives virus-host membrane fusion. Here, we analyze the role of each amino acid in E1E2 function, expressing 545 individual alanine mutants of E1E2 in human cells, incorporating them into infectious viral pseudoparticles, and testing them against 37 different monoclonal antibodies (MAbs) to ascertain full-length translation,...

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PMID: 35613596
DOI: 10.1016/j.celrep.2022.110859

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