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Article

Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.

Journal of virology - 1 Nov 2012

Brown Richard J P, Hudson Natalia, Wilson Garrick, Rehman Shafiq Ur, Jabbari Sara, Hu Ke, Tarr Alexander W, Borrow Persephone, Joyce Michael, Lewis Jamie, Zhu Lin Fu, Law Mansun, Kneteman Norman, Tyrrell D Lorne, McKeating Jane A, Ball Jonathan K

Abstract excerpt

Genetic variability is a hallmark of RNA virus populations. However, transmission to a new host often results in a marked decrease in population diversity. This genetic bottlenecking is observed during hepatitis C virus (HCV) transmission and can arise via a selective sweep or through the founder effect. To model HCV transmission, we utilized chimeric SCID/Alb-uPA mice with transplanted human hepatocytes and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22855498
DOI: 10.1128/JVI.01079-12
PMCID: PMC3486514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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