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Article

Immunoglobulin mimicry by Hepatitis C Virus envelope protein E2.

Virology - 20 Feb 2005

Hu Yu-Wen, Rocheleau Lynda, Larke Bryce, Chui Linda, Lee Bonita, Ma Mang, Liu Song, Omlin Teye, Pelchat Martin, Brown Earl G

Abstract excerpt

Hepatitis C virus (HCV) establishes persistent infection in the majority of infected individuals. The currently accepted hypothesis of immune evasion by antigenic variation in hypervariable region 1 (HVR1) of glycoprotein E2 does not however, explain the lack of subsequent immune recognition. Here, we show that the N-terminal region of E2 is antigenically and structurally similar to human immunoglobulin (Ig)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, Antigen, T-Cell

Share to Sequence Homology, Amino Acid

Share to Vaccines, Synthetic

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Source

Identifiers

PMID: 15680419
DOI: 10.1016/j.virol.2004.11.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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