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Article

Widespread intra-dependencies in the removal of introns from human transcripts.

Nucleic acids research - 19 Sept 2017

Kim Seong Won, Taggart Allison J, Heintzelman Claire, Cygan Kamil J, Hull Caitlin G, Wang Jing, Shrestha Barsha, Fairbrother William G

Abstract excerpt

Research into the problem of splice site selection has followed a reductionist approach focused on how individual splice sites are recognized. Early applications of information theory uncovered an inconsistency. Human splice signals do not contain enough information to explain the observed fidelity of splicing. Here, we conclude that introns do not necessarily contain 'missing' information but rather may require...

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PMID: 28934498
DOI: 10.1093/nar/gkx661
PMCID: PMC5766209

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