Article

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

2023-01-03

Abstract excerpt

The key cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) is essential to elicit anti-infection innate immunity whereas aberrant activation of cGAS by endogenous DNA promotes severe autoimmune diseases, thus the activity of cGAS must be strictly regulated to maintain immune homeostasis. Here we report that the E3 ISG15-protein ligase HERC5 interacts with and catalyzes the cGAS ISGylation robustly, wher...

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Identifiers and source

Literature Corpus work: 7914c859-2025-5375-a14e-15da9df2a6cf
DOI: 10.1101/2023.01.03.522548

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